vWD III | Animal Genetics

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von Willebrand's Disease Type III

Description:

Von Willebrand disease (vWD) is the most comon inherited bleeding disorder found in dogs and humans. vWD inhibits the normal blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience excessive bruising, prolonged nosebleeds, and excessive bleeding following any form of trauma, including surgery, or dental work.

 

The primary function of von Willebrand factor (vWF) a blood glycoprotein, is to bind itself to other proteins. The deficiency or failure of vWF function inhibits the blood coagulation process and causes bleeding which is most apparent in tissues having high blood flow or narrow vessels.

Von Willebrand's disease type I (vWDIII) :

In dogs (as well as in people), three separate types of vWD have been identified. Of these three types there are five different genetic mutations causing vWDs in dogs. Genetic tests have been developed to identify all five variants. Von Willebrand's disease type III (VWDIII) is transmitted as an autosomal recessive trait and is the most serious of the three. vWDIII affected animals do not produce any von Willebrand Factor protein in their blood.

 

A different genetic mutation causes vWDIII in each of the following:

Type A Scottish Terrier

Type B Shetland Sheepdog

Type C Kooikerhondje

Sample Type:

Animal Genetics accepts buccal swab, blood, and dewclaw samples for testing. Sample collection kits are available and can be ordered at Canine Test Now.

Test Is Relevant to the Following Breeds:

Animal Genetics is currently only offering testing for von Willebrand's Disease Type III. This mutation has been detected in the following breeds:

 

Scottish Terrier, Shetland Sheepdog, Kooikerhondje

Results:

Animal Genetics offers DNA testing for von Willebrand's Disease type III. The genetic test verifies the presence of the vWD mutation and presents results as one of the following:

vWDIII/vWDIII Affected The dog carries two copies of the mutant gene and is homozygous for the mutation associated with von Willebrand's disease type III. The dog IS affected and will always pass a copy of the mutation to its offspring.
vWDIII/n Carrier Both the normal and mutant copies of the gene detected. Dog is a carrier for the von Willebrand's disease type III mutation. The dog is NOT affected but will pass on a copy of the defective gene to its offspring 50% of the time.
n/n Clear Dog tested negative for the von Willebrand's Disease type III mutation and will not pass on the defective gene to its offspring.

Reference:

Thromb Haemost. 1998 Aug;80(2):332-7. Identification of mutations in the canine von Willebrand factor gene associated with type III von Willebrand disease. Rieger M1, Schwarz HP, Turecek PL, Dorner F, van Mourik JA, Mannhalter C.